32 research outputs found
Coulomb interaction between a spherical and a deformed nuclei
We present analytic expressions of the Coulomb interaction between a
spherical and a deformed nuclei which are valid for all separation distance. We
demonstrate their significant deviations from commonly used formulae in the
region inside the Coulomb radius, and show that they remove various
shortcomings of the conventional formulae.Comment: 7 pages 4 figure
Superconductivity of the spin ladder system: Are the superconducting pairing and the spin-gap formation of the same origin?
Pressure-induced superconductivity in a spin-ladder cuprate
SrCaCuO has not been studied on a microscopic level so
far although the superconductivity was already discovered in 1996. We have
improved high-pressure technique with using a large high-quality crystal, and
succeeded in studying the superconductivity using Cu nuclear magnetic
resonance (NMR). We found that anomalous metallic state reflecting the
spin-ladder structure is realized and the superconductivity possesses a
s-wavelike character in the meaning that a finite gap exists in the
quasi-particle excitation: At pressure of 3.5GPa we observed two excitation
modes in the normal state from the relaxation rate . One gives rise
to an activation-type component in , and the other -linear
component linking directly with the superconductivity. This gapless mode likely
arises from free motion of holon-spinon bound states appearing by hole doping,
and the pairing of them likely causes the superconductivity.Comment: to be published in Phys. Rev. Let
Survey of Period Variations of Superhumps in SU UMa-Type Dwarf Novae. VIII: The Eighth Year (2015-2016)
Continuing the project described by Kato et al. (2009, arXiv:0905.1757), we
collected times of superhump maxima for 128 SU UMa-type dwarf novae observed
mainly during the 2015-2016 season and characterized these objects. The data
have improved the distribution of orbital periods, the relation between the
orbital period and the variation of superhumps, the relation between period
variations and the rebrightening type in WZ Sge-type objects. Coupled with new
measurements of mass ratios using growing stages of superhumps, we now have a
clearer and statistically greatly improved evolutionary path near the terminal
stage of evolution of cataclysmic variables. Three objects (V452 Cas, KK Tel,
ASASSN-15cl) appear to have slowly growing superhumps, which is proposed to
reflect the slow growth of the 3:1 resonance near the stability border.
ASASSN-15sl, ASASSN-15ux, SDSS J074859.55+312512.6 and CRTS J200331.3-284941
are newly identified eclipsing SU UMa-type (or WZ Sge-type) dwarf novae.
ASASSN-15cy has a short (~0.050 d) superhump period and appears to belong to EI
Psc-type objects with compact secondaries having an evolved core. ASASSN-15gn,
ASASSN-15hn, ASASSN-15kh and ASASSN-16bu are candidate period bouncers with
superhump periods longer than 0.06 d. We have newly obtained superhump periods
for 79 objects and 13 orbital periods, including periods from early superhumps.
In order that the future observations will be more astrophysically beneficial
and rewarding to observers, we propose guidelines how to organize observations
of various superoutbursts.Comment: 123 pages, 162 figures, 119 tables, accepted for publication in PASJ
(including supplementary information
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes. For example, a key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process versus those that measure fl ux through the autophagy pathway (i.e., the complete process including the amount and rate of cargo sequestered and degraded). In particular, a block in macroautophagy that results in autophagosome accumulation must be differentiated from stimuli that increase autophagic activity, defi ned as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (inmost higher eukaryotes and some protists such as Dictyostelium ) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the fi eld understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. It is worth emphasizing here that lysosomal digestion is a stage of autophagy and evaluating its competence is a crucial part of the evaluation of autophagic flux, or complete autophagy. Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to monitor autophagy. Along these lines, because of the potential for pleiotropic effects due to blocking autophagy through genetic manipulation it is imperative to delete or knock down more than one autophagy-related gene. In addition, some individual Atg proteins, or groups of proteins, are involved in other cellular pathways so not all Atg proteins can be used as a specific marker for an autophagic process. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular autophagy assays, we hope to encourage technical innovation in the field
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CTGF/CCN2 facilitates LRP4-mediated formation of the embryonic neuromuscular junction.
At the neuromuscular junction (NMJ), lipoprotein-related receptor 4 (LRP4) mediates agrin-induced MuSK phosphorylation that leads to clustering of acetylcholine receptors (AChRs) in the postsynaptic region of the skeletal muscle. Additionally, the ectodomain of LRP4 is necessary for differentiation of the presynaptic nerve terminal. However, the molecules regulating LRP4 have not been fully elucidated yet. Here, we show that the CT domain of connective tissue growth factor (CTGF/CCN2) directly binds to the third beta-propeller domain of LRP4. CTGF/CCN2 enhances the binding of LRP4 to MuSK and facilitates the localization of LRP4 on the plasma membrane. CTGF/CCN2 enhances agrin-induced MuSK phosphorylation and AChR clustering in cultured myotubes. Ctgf-deficient mouse embryos (Ctgf-/- ) have small AChR clusters and abnormal dispersion of synaptic vesicles along the motor axon. Ultrastructurally, the presynaptic nerve terminals have reduced numbers of active zones and mitochondria. Functionally, Ctgf-/- embryos exhibit impaired NMJ signal transmission. These results indicate that CTGF/CCN2 interacts with LRP4 to facilitate clustering of AChRs at the motor endplate and the maturation of the nerve terminal